Journal of pharmacological sciencesAnimalsSodium-Glucose Transporter 2 InhibitorsUreaMaleFatty Liver
SGLT2 inhibitor-induced glycosuria improves steatotic liver disease in parallel with enhanced ureagenesis in ob/ob mice.
Satoshi Kidoguchi, Kento Kitada, Asahiro Morishita, Yudai Tsuji, Hiroyuki Ohsaki, Daisuke Yamazaki, Takashi Morikawa, Yoshio Konishi, Hideki Kobara, Takashi Yokoo, Jens Titze, Kazuo Takahashi, Akira Nishiyama
Published: 202610.1016/j.jphs.2025.12.006
Abstract
PURPOSE: Recent studies have reported that sodium-glucose cotransporter (SGLT) 2 inhibitors ameliorate steatotic liver disease. We investigated the contribution of SGLT2 inhibitor-induced fluid loss due to glycosuria in hepatic ureagenesis for water…
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