Journal of pharmacological sciencesHumansNeurodegenerative DiseasesRNADrug DiscoveryG-Quadruplexes
RNA-mediated aggregation mechanism of prion-like proteins and its application to drug discovery.
Yasushi Yabuki, Norifumi Shioda
Published: 202610.1016/j.jphs.2025.11.006
Abstract
Neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease are on the rise in super-aging societies. However, the mechanisms underlying the aggregation and propagation of prion-like proteins such as α-synuclein and Tau that contr…
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