Journal of pharmacological sciencesOxaliplatinProton Pump InhibitorsAnimalsPeripheral Nervous System DiseasesMale
Class effects of proton pump inhibitors in preventing oxaliplatin-induced peripheral neurotoxicity.
Yusuke Mori, Keisuke Mine, Takehiro Kawashiri, Yusuke Koura, Mami Ueda, Risa Kaneko, Shunsuke Fujita, Akito Tsuruta, Satoru Koyanagi, Daisuke Kobayashi
Published: 202510.1016/j.jphs.2025.09.010
Abstract
Oxaliplatin-induced peripheral neuropathy (OIPN) is a dose-limiting toxicity with limited countermeasures. Basic research has revealed that omeprazole, a proton pump inhibitor (PPI), exerts preventive effects against OIPN. In this study, we evaluated…
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