Journal of pharmacological sciencesMembrane ProteinsNephrotic SyndromeHigh-Throughput Screening AssaysHumansCell Membrane
Establishing a nanoluciferase-based assay as a high-throughput screening platform for therapeutics in congenital nephrotic syndrome.
Haruki Tsuhako, Mary Ann Suico, Haruka Kojima, Saki Takahashi, Shunsuke Tanigawa, Misato Kamura, Ryoichi Sato, Riko Kato, Aimi Owaki, Ryuichi Nishinakamura, Tsuyoshi Shuto, Hirofumi Kai
Published: 202510.1016/j.jphs.2025.09.006
Abstract
Nephrin is crucial for the formation of the glomerular slit diaphragm, which is the final filtration barrier in the kidney. A mutation in the NPHS1 gene that codes for nephrin causes congenital nephrotic syndrome of the Finnish type (CNF). Most misse…
Preview only. Read the full abstract at the source