Journal of photochemistry and photobiology. B, Biology
Transcriptomic and functional profiling reveal autophagy inhibition and persistent bioenergetic collapse following parallel photodamage to lysosomes and mitochondria.
Márcia Silvana Freire Franco, Felipe Gustavo Ravagnani, Suely Kazue Nagahashi Marie, Sueli Mieko Oba-Shinjo, Leonardo Vinicius Monteiro de Assis, Maurício S Baptista
Published: 202610.1016/j.jphotobiol.2026.113364
Abstract
Photodynamic therapy (PDT) using 1,9-dimethyl methylene blue (DMMB) induces coordinated mitochondrial and lysosomal damage and results in strong cellular death induction. However, the underlying transcriptional regulation in response to DMMB remains…
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