The Journal of pharmacology and experimental therapeutics
Lithium, a GSK-3β inhibitor, attenuates depression and chemobrain induced by doxorubicin in rats: Emphasis on brain BDNF/TrkB/Akt/GSK-3β/mTOR/Nrf2/HO-1 axis.
Sawsan Aboul-Fotouh, Esraa M Elnahas, Afifi A Alafifi, Manar Yehia Ahmed, Ahmed M Taha
Published: 202510.1016/j.jpet.2025.103797
Abstract
Although chemotherapy remains a life-saving intervention for numerous cancer patients, it is often accompanied by depressive symptoms and cognitive impairments, "chemobrain." Noteworthy, multiple studies emphasize the role of glycogen synthase kinase…
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