The Journal of pharmacology and experimental therapeutics
Naringenin-functionalized polyester nanoparticles improve oral urolithin A delivery and protect against cisplatin-induced kidney injury via heme oxygenase-1 activation and mitochondrial quality control.
Abiodun T Wahab, Raghu Ganugula, David Sheikh-Hamad, Subhashini Bolisetty, Meenakshi Arora, M N V Ravi Kumar
Published: 202510.1016/j.jpet.2025.103794
Abstract
Cisplatin remains a cornerstone of chemotherapy, but its clinical use is often limited by cisplatin-induced acute kidney injury, a condition driven by oxidative stress, inflammation, and mitochondrial dysfunction. Here, we developed naringenin-functi…
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