The Journal of pharmacology and experimental therapeuticsAnimalsSubstance Withdrawal SyndromeMaleRatsSprague-Dawley
Spontaneous daily sleep disruptions associated with morphine dependence and withdrawal in rats.
Harlie A McKelvey, Bethany E Pierce, Jesse M Lynch, Audrey L Kim, Kimberly M Holter, Reto A Gadient, Douglas J Sheffler, Gonul Velicelebi, Nicholas D P Cosford, Robert W Gould
Published: 202510.1016/j.jpet.2025.103766
Abstract
Sleep disturbances are prominent symptoms of opioid withdrawal that contribute to relapse in individuals with opioid use disorder (OUD). Although preclinical studies often examine protracted withdrawal after sustained abstinence, few address the repe…
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