The Journal of pharmacology and experimental therapeuticsHumansProteolysisSenotherapeuticsAnimalsAging
Proteolysis targeting chimeras as senolytics: An emerging senotherapy for combating aging.
Alexis B Cruickshank-Taylor, Jacob S Kozora, Jennifer S Carew, Steffan T Nawrocki, Wei Wang
Published: 202510.1016/j.jpet.2025.103752
Abstract
Cellular senescence, a persistent state of cell cycle arrest, accumulates in aged organisms, contributes to tissue dysfunction, and drives aging-related phenotypes. Clearance of senescent cells decreases chronic, low-grade inflammation and restores t…
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