The Journal of pharmacology and experimental therapeuticsTRPA1 Cation ChannelEnteroendocrine CellsMiceAnimalsCell Line
Prevention of fatty acid-induced maladaptation in secretin tumor cell-1 enteroendocrine cells by allicin, a transient receptor potential ankyrin 1 agonist.
Neha Mahajan, Roshan Lal, Vijay Kumar, Pragyanshu Khare, Ritesh Kumar Baboota, Priyanka Rana, Neelima Dhingra, Andrzej Lewiński, Małgorzata Karbownik-Lewińska, Adam Gesing, Kanthi Kiran Kondepudi, Mahendra Bishnoi
Published: 202510.1016/j.jpet.2025.103728
Abstract
Enteroendocrine cells (EECs) in the gastrointestinal tract play a critical role in sensing dietary fat and regulating the secretion of gut hormone. However, chronic high-fat diet (HFD) intake can lead to maladaptive changes in these cells, impairing…
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