The Journal of pharmacology and experimental therapeuticsMicroRNAsMetforminNF-kappa BLipopolysaccharidesAnimals
Protective functions of metformin in LPS-induced H9C2 injury by miR-497-5p/BTRC/IκBα axis-mediated NF-κB pathway activation.
Fan Xiao-Guang, Li Shu-Yuan, Cui Wen-Juan, Zhang Zhi-Kun, Hong Shu-Kun, Yang Guang-Hu, Liu Jian, Zhang Xue-Zhong, Wang Heng, Qiao Lu-Jun, Li Hua
Published: 202510.1016/j.jpet.2025.103703
Abstract
Sepsis is a life-threatening organ dysfunction syndrome triggered by infection and uncontrolled inflammatory responses, with sepsis-associated myocardial dysfunction being a leading cause of mortality and morbidity. Metformin, a widely prescribed ant…
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