Journal of pharmaceutical and biomedical analysis
LC-MS peptide mapping of monoclonal antibodies using the mirror proteases trypsin and Tryp-N.
Domantas Sargautis, Bernd Thiede
Published: 202610.1016/j.jpba.2026.117361
Abstract
Accurate characterization of the amino acid sequence and post translational modifications (PTMs) of monoclonal antibodies (mAbs) is essential for evaluating product quality. Peptide mapping through bottom-up LC/MS analysis is a key methodology for th…
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