Journal of pharmaceutical and biomedical analysisHumansSolid Phase ExtractionCysteineSerum AlbuminHuman
Efficient analytical set-up for the monitoring of albumin adduction on Cysteine 34 exposed to mustard agents with optimized digestion and on-line SPE-LC-MS analysis.
Lorenzo Avigo, Marine Charpin, Audrey Combès, Charlotte Desoubries, Christine Albaret, Anne Bossée, Emmanuel Joubert, Valérie Pichon
Published: 202610.1016/j.jpba.2025.117324
Abstract
Adduction of mustard agents such as sulfur mustard (SM), sesquimustard (Q), and nitrogen mustards (HN-1, HN-2, HN-3) on nucleophilic sites of proteins, particularly Cysteine34 of human serum albumin (HSA), can be monitored in plasma to confirm retros…
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