Journal of pharmaceutical and biomedical analysisChromatographySupercritical FluidDrug ContaminationStereoisomerismPyrrolidinones
Economical chiral and achiral separation of seven impurities in brivaracetam by supercritical fluid chromatography with polysaccharide-based chiral stationary phases.
Qingying Jia, Xiaodan Qiu, Xuejia Zhao, Huiyi Liu, Yongsheng Gu, Kun Xiao, Xinran Zhang, Xun Ma, Guangzhi Shan
Published: 202610.1016/j.jpba.2025.117287
Abstract
Due to the presence of multiple chiral centers in its structure, the analysis of brivaracetam and its enantiomers, diastereomers, as well as non-isomeric impurities imposes high requirements on the separation capability of chromatographic methods. In…
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