Journal of pharmaceutical and biomedical analysisHumansSunitinibTandem Mass SpectrometryNailsSkin
Development of an LC-MS/MS method for the quantification of sunitinib and its metabolites in human nail and skin.
Miki Takenaka Sato, Takuya Araki, Hideaki Yashima, Jun Morita, Yoshiko Maeda, Masayuki Ohbayashi, Noriko Kohyama, Yoshio Ogawa, Takashi Fukagai, Koujirou Yamamoto, Mari Kogo
Published: 202610.1016/j.jpba.2025.117242
Abstract
Sunitinib is associated with a high incidence of hand-foot skin reaction (HFSR) that significantly affects the quality of life and treatment continuation of the patient. The relationships between the concentrations of sunitinib and its metabolites in…
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