Journal of pharmaceutical and biomedical analysisColistinHumansDrug MonitoringTandem Mass SpectrometryAnti-Bacterial Agents
Automated magnetic bead‑based LC-Triple Quadrupole MS approach for sensitive colistin therapeutic drug monitoring in human plasma.
Fangqiong Li, Juan Wang, Xiaoting Gong, Ji Shen, Qiuyu Zhu, Chuanwei Xin, Wei Zhang, Haiying Wu, Huifang Jiang, Yuexing Tu
Published: 202610.1016/j.jpba.2025.117224
Abstract
Colistin, a cationic peptide antibiotic produced by Bacillus polymyxa subsp. colistinus, is a last-line defense against multidrug-resistant Gram-negative bacteria. However, its clinical utility is hampered by significant nephrotoxicity and neurotoxic…
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