Osteoarthritis and cartilage
The impact of screening period pain inconsistency on placebo response in intra-articular knee osteoarthritis trials.
Jakob Mejdahl Bentin, Ida Sofie Adrian, Alejandro Castillo Mondragon, Andrea Bak Kaaber, Claire Prener Miller, Peter Alexandersen, Lars Arendt-Nielsen, Asger Reinstrup Bihlet
Published: 202510.1016/j.joca.2025.10.018
Abstract
OBJECTIVE: Placebo response (PR) presents a significant challenge in osteoarthritis (OA) trials. Screening Period Pain Inconsistency (SPPI) has been associated with heightened PR in placebo-treated patients. However, existing studies have overlooked…
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