The Journal of nutritional biochemistryAnimalsAcetaminophenAcetylcysteineHydrogenChemical and Drug Induced Liver Injury
Molecular hydrogen mitigates acetaminophen-induced liver injury and enhances the effects of N-acetylcysteine in diabetic mice.
Naomi Kamimura, Katsuya Iuchi, Tsutomu Igarashi, Ikuroh Ohsawa, Chikako Nito, Jitsuo Usuda, Shigeo Ohta
Published: 202610.1016/j.jnutbio.2025.110176
Abstract
Acetaminophen (APAP) overdose induces severe liver injury, especially in diabetic patients. N-acetylcysteine (NAC) is commonly used as an approved antidote for APAP toxicity; however, its narrow therapeutic window limits its clinical utility. This st…
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