The Journal of nutritional biochemistryAnimalsGastrointestinal MicrobiomeDietHigh-FatMale
UPP1 as a potential target for astilbin in ameliorating high-fat diet-induced bone loss via MAPK signaling: a study incorporating gut microbiota and metabolomics.
Hui Su, Luyao Liu, Zechen Yan, Jun Dong, Xianze Chen, Lin Wang, Guangxin Huang, WenXuan Guo, Rujie Zhuang, Yu Pan
Published: 202610.1016/j.jnutbio.2025.110140
Abstract
This study aims to investigate the therapeutic effects and underlying mechanisms of astilbin on high-fat diet (HFD)-induced bone loss, focusing on its regulation of the UPP1-Mitogen-Activated Protein Kinase (MAPK) axis, metabolic reprogramming, and g…
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