Journal of neuroimmunologyHumansAntibodiesMonoclonalHumanizedAstrocytes
Iatrogenic NORSE: Immune checkpoint inhibitor-related anti-GFAP autoimmune astrocytopathy.
Chiara Marotta, Elisabetta Rolla, Martina Fabris, Rossana Domenis, Jérôme Honnorat, Donatella Iacono, Giuseppe Aprile, Mariarosaria Valente, Alberto Vogrig
Published: 202610.1016/j.jneuroim.2025.578805
Abstract
Immune checkpoint inhibitors (ICIs) have radically improved cancer therapy but are associated with a spectrum of immune-related adverse events (irAEs), including infrequent (1-3 %) neurological complications. Pembrolizumab, an anti-PD-1 monoclonal an…
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