The Journal of molecular diagnostics : JMDHumansErbB ReceptorsHigh-Throughput Nucleotide SequencingGlioblastomaSequence Analysis
Enhanced Detection of EGFRvIII in Tumors: A Comparative Study of Split Read- and Read Depth-Based DNA Sequencing Approaches.
Nan Chen, Jingjing Feng, Dong Wan, Dongbing Li, Sheng Xiao
Published: 202610.1016/j.jmoldx.2025.11.002
Abstract
Epidermal growth factor receptor variant (EGFRv)-III, a common oncogenic variant in glioblastoma and other solid tumors, results from an in-frame deletion of exons 2 to 7 from the EGFR gene. Detection of EGFRvIII is crucial for understanding tumor bi…
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