Journal of molecular graphics & modellingPseudomonas putidaMolecular Dynamics SimulationProtein MultimerizationSteroid IsomerasesTemperature
Molecular dynamics insights into dimerization-dependent catalysis and thermal adaptation of mesophilic ketosteroid isomerase from Pseudomonas putida.
Yi-Zhe Wang, Tzu-En Lin, Yu-Shan Tsai, Hsuan-Hsuan Lo, Chia-Ning Yang
Published: 202610.1016/j.jmgm.2025.109230
Abstract
Ketosteroid isomerase (KSI), a highly conserved enzyme in the β-ketoacyl metabolic pathway, exhibits temperature-dependent functional adaptations across species. In this study, we investigated the temperature sensitivity of mesophilic KSI from Pseudo…
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