Journal of inorganic biochemistryHumansAntineoplastic AgentsOxaliplatinCisplatinProdrugs
Triple-action Pt(IV) prodrugs of cisplatin and oxaliplatin with indole propionate and 4-phenylbutyrate ligands as potent anticancer agents.
Leila Tabrizi, Alan M Jones, Isolda Romero-Canelon, Andrea Erxleben
Published: 202610.1016/j.jinorgbio.2025.113183
Abstract
The synthesis and biological activity of two new platinum(IV) derivatives of cisplatin and oxaliplatin with indole-3-propionate (IPA) and the histone deacetylase inhibitor 4-phenylbutyrate (PBA) in axial position are reported. Cis,cis,trans-[Pt(NH3)2…
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