The Journal of investigative dermatology
Connectivity mapping with isotretinoin's transcriptomic signature identifies alternative therapeutics for severe acne.
Mackenzie L Sennett, Robert P Feehan, Tierney E Wallace, Samantha L Gettle, Amy L Longenecker, Andrea L Zaenglein, Diane M Thiboutot, Amanda M Nelson
Published: 202510.1016/j.jid.2025.11.025
Abstract
Isotretinoin, the gold-standard treatment for severe acne, effectively targets major pathogenic factors but carries teratogenic risks. Its precise mechanism of action remains incompletely understood. Computational approaches, such as connectivity map…
Preview only. Read the full abstract at the source