The Journal of investigative dermatology
Single-cell and spatial transcriptomics implicate vascular cell orchestration of inflammatory changes after UV light exposure in skin.
Jie An, Rachael Bogle, Rayan Najjar, Lam C Tsoi, J Michelle Kahlenberg, Ksenia Anufrieva, Erin Theisen, Kevin Wei, Johann E Gudjonsson, Keith B Elkon
Published: 202510.1016/j.jid.2025.11.024
Abstract
To elucidate the complex effects of acute UVR on the skin, we exposed mouse skin to UVB and performed transcriptomic profiling of the epidermis, deep dermis, and adipose tissue. Spatial transcriptomic analysis revealed gene expression changes in the…
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