The Journal of investigative dermatology
Phenotype switching in melanoma cells: MITF regulates the expression of CDH1 through E-boxes in an intronic region.
Evangeline Breeta Raja David Isac, Sara Sigurbjörnsdóttir, Ramile Dilshat, Robert A Cornell, Colin Kenny, Eiríkur Steingrímsson
Published: 202510.1016/j.jid.2025.11.008
Abstract
Melanoma cells evade drug treatment by changing their phenotype from proliferative to migrative cells and vice versa in a process known as phenotype switching. The Microphthalmia-associated transcription factor (MITF) is a key regulator of phenotype…
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