Journal of infection and chemotherapy : official journal of the Japan Society of ChemotherapyAnimalsCefepimeMicrobial Sensitivity TestsMiceKlebsiella pneumoniae
Application of epithelial lining fluid drug concentrations to MICi-Based PK/PD modeling of cefepime/nacubactam in a murine model of CPE pneumonia.
Yuki Mizukami, Mishu Takahashi, Kenta Suzuki, Shaoqing Duan, Shintaro Ikegami, Takuma Muraishi, Natsuki Satake, Yuko Okamoto, Yuki Igarashi, Yuki Enoki, Kazuaki Taguchi, Kazuaki Matsumoto
Published: 202610.1016/j.jiac.2025.102889
Abstract
INTRODUCTION: Nacubactam is a novel β-lactamase inhibitor with intrinsic antibacterial activity that shows therapeutic potential against carbapenemase-producing Enterobacterales when administered with β-lactam antibiotics. Pharmacokinetics/pharmacody…
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