Journal of hepatology
AF6 knockout-induced upregulation of bile acid production promotes CXCL14-mediated antitumor immunity in HCC: Effect of the BA/Butyrate/CXCL14 axis in HCC.
Keying Xu, Xiaoxia Dong, Huiheng Qu, Jiayang Hu, Jiazheng Jiao, Rongrong Chen, Gang Li, Zhaoshen Li, Xiao Xu, Jiazeng Xia, Lixing Zhan
Published: 202610.1016/j.jhep.2025.12.029
Abstract
BACKGROUND & AIMS: Bile acid (BA) metabolism has been found to play an important role in the progression of liver cancer, but the specific mechanism is poorly understood. Hepatic afadin (AF6) is implicated in primary BA synthesis, but its role in mod…
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