Journal of hepatology
Single nucleotide polymorphisms in the bepirovirsen binding site have limited impact on treatment response in chronic hepatitis B.
Jerome Bouquet, Scott D Speer, Alexander Koenig, Christine M Livingston, Michael Savarese, Chi Lau, Elise Angelini, Nicholas Galwey, Phillip Yates, Lauren Maynard, Shihyun You, Jennifer Cremer, Melanie Paff, Dickens Theodore, Rob Elston
Published: 202610.1016/j.jhep.2025.12.025
Abstract
BACKGROUND AND AIMS: Single nucleotide polymorphisms (SNPs) in the hepatitis B virus (HBV) genome may impact efficacy of novel drugs for chronic HBV infection. This analysis of the B-Clear study (NCT04449029) evaluated the frequency of baseline and t…
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