Journal of hazardous materialsToll-Like Receptor 4PodocytesDiethylhexyl PhthalateAnimalsHumans
Mono(2-ethylhexyl) phthalate activates JNK signaling via TLR4-MD2 binding to induce podocyte injury in chronic kidney disease.
Jiajun Jing, Shaohui Liu, Li Yan, Li'e Zhang, Qiuju Liang, Yuting Wen, Xiaofeng Huang, Zijuan Qi, Mingjun Wang, Zi'ang Huang, Sijin Liu, Yunfeng Zou, Ming Gao
Published: 202610.1016/j.jhazmat.2025.140637
Abstract
Phthalates (PAEs), widely used in plastics and consumer products, have raised growing concern due to the potential adverse health effects of their metabolites. While several epidemiological studies have linked PAE metabolites to nephrotoxicity, most…
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