Journal of hazardous materialsAnimalsDiethylhexyl PhthalatePyroptosisSphingolipidsMyocytes
A new insight into the mechanism of DEHP-induced cardiotoxicity: Triggering pyroptosis of cardiomyocytes by disrupting sphingolipid metabolism.
Jia-Gen Cui, Hao Zhang, Yue-Qi Zhang, Bing Sun, Xue-Nan Li, Yi Zhao, Jin-Long Li
Published: 202510.1016/j.jhazmat.2025.140148
Abstract
The widespread use of di(2-ethylhexyl) phthalate (DEHP) as a plasticizer raises concerns due to its environmental persistence and cardiotoxicity. Nevertheless, the precise mechanisms through which DEHP induces cardiac damage, particularly concerning…
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