Triterpenoid saponins from Platycodon grandiflorus exhibit antidepressant-like effects and are associated with BDNF-mediated neuroplasticity signaling in a chronic stress model.

ETHNOPHARMACOLOGICAL RELEVANCE: The roots of Platycodon grandiflorus (Jacq.) A. DC. (Campanulaceae), known as Platycodi Radix (PR), have long been used as a traditional medicine for respiratory ailments and for relieving chest oppression, a symptom a…

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