Journal of ethnopharmacology
Integrated network pharmacology and multi-omics reveals GLUD1-mediated α-KG/Glu conversion in regulating amino acid metabolism: a mechanism of Dangua Fang against type 2 diabetes mellitus.
Zhuang Han, Liuqing Yang, Zhita Wang, Liang Li, Linxi Jin, Qiwei Chen, Shuhong Yao, Xinmiao Hong, Caizuan Zhang, Jinyong Xu, Hua Huang, Guoli Shang, Yuwei Lin, Ting Song, Xianpei Heng
Published: 202610.1016/j.jep.2026.121198
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE: Amino acid metabolic disorder is one of the typical features of diabetes. The tricarboxylic acid (TCA) cycle serves as a central hub for carbon-nitrogen metabolism, with α-ketoglutarate (α-KG)/glutamate (Glu) conversio…
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