Journal of ethnopharmacologyLung NeoplasmsAnimalsHumansReceptorTransforming Growth Factor-beta Type II
Amentoflavone from Ginkgo biloba inhibits EMT-driven lung cancer metastasis by targeting TGFBR2: Integrative network pharmacology, machine learning, and experimental validation.
Kaile Liu, Kaiting Chen, Xiaoxue Zhao, Yahui Zhang, Yuejiao Cai, Xiaojie Fu, Zhongqi Wang, Juying Jiao, Haibin Deng
Published: 202610.1016/j.jep.2025.121061
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE: In non-small cell lung cancer (NSCLC), fatal outcomes predominantly result from metastatic dissemination, highlighting an urgent need for metastasis-directed therapies. Amentoflavone (AMF), a natural biflavonoid found…
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