Citrus-caspase-4-serotonin axis: Aurantii Fructus rapidly reverses chronic-stress-induced despair via suppression of hippocampal caspase-4.

ETHNOPHARMACOLOGICAL RELEVANCE: The citrus-derived flavonoid-rich fraction Aurantii Fructus (AF) has been traditionally used in East Asian folk medicine to relieve mood-related complaints, yet its antidepressant profile and mechanism remain ill-defin…

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