Journal of ethnopharmacologyAnimalsSaponinsMesenchymal Stem CellsHumansAstragalus Plant
Total astragalus saponins enhance the anti-liver fibrosis efficacy of Numb-overexpressed hUC-MSCs through stabilizing the Numb-p53 axis.
Shi-Hao Zhang, Ming-Yan Yang, Yan-Nan Xu, Fei-Fei Xing, Jun-Yi Zhan, De-Xin Wang, Jia-Mei Chen, Gao-Feng Chen, Ping Liu, Wei Liu, Yong-Ping Mu
Published: 202610.1016/j.jep.2025.120980
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE: Astragali Radix (Huangqi), a traditional Chinese medicine documented in Shennong Bencao Jing (ca. 200 AD), has been used for chronic liver disease. Total astragalus saponins (TAS), its primary bioactive component, exhi…
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