Journal of ethnopharmacologyAnimalsArthritisExperimentalMolecular Docking SimulationPlant Roots
Dendropanax proteus root and its major bio-phytochemicals alleviate rheumatoid arthritis by inhibiting TLR4/CLEC1B/PI3K/Akt/NF-κB pathways: proteomics, metabolomics, collagen-induced arthritis rats, MH7A cells, molecular docking, and molecular dynamic simulation.
Li Yang, Yating Yang, Qihui Wang, Jian Liang, Shengyuan Zhang, Hua Nie, Huang Zeng, Junwei He
Published: 202610.1016/j.jep.2025.120903
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE: Dendropanax proteus (Champ.) Benth. root (DPR) is a traditional anti-rheumatoid arthritis (RA) plant in China. However, its bio-phytochemicals, effect, and mechanism against RA remain unclear. AIM OF THE STUDY: To expl…
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