Journal of ethnopharmacologyAnimalsNF-E2-Related Factor 2Oxidative StressFerroptosisFibrosis
Shen-Shuai-II-Recipe suppresses hypoxia-induced oxidative stress and ferroptosis via Nrf2 activation to ameliorate renal fibrosis in chronic kidney disease.
Yizeng Xu, Meng Wang, Lingchen Wang, Xinyue Zhang, Gangyi Chen, Chen Wang
Published: 202610.1016/j.jep.2025.120783
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE: Shen-Shuai-II-Recipe (SSR), a clinically effective Chinese herbal formula for chronic kidney disease (CKD) management, has shown potential anti-hypoxia and anti-fibrosis properties in rat models of CKD. However, the un…
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