Journal of ethnopharmacologyAnimalsNF-E2-Related Factor 2Oxidative StressSirtuinsDiabetic Retinopathy
Sappanone A alleviates high glucose-induced retinal oxidative injury and mitochondrial dysfunction via SIRT7/NRF2 pathway.
Xinchen Wang, Siyu Gui, Xiaoyan Liu, Zhihao Huang, Heting Liu, Jie Gao
Published: 202610.1016/j.jep.2025.120774
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE: Diabetic retinopathy (DR) is a major microvascular complication of diabetes characterized by oxidative stress, mitochondrial dysfunction, and inflammation. Sappanone A (SA), a natural flavonoid derived from Caesalpinia…
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