Cytotherapy
Ex vivo mesenchymal progenitor cell-based cord blood cell expansion and exofucosylation to enhance transplant engraftment.
Portia Smallbone, Mayela Mendt, Robert Sackstein, Mark R Tanner, Indresh Kaur, Rafet Basar, Hind Rafei, May Daher, Bethany Overman, Gheath Al-Atrash, Amin M Alousi, Qaiser Bashir, Chitra M Hosing, Jin S Im, Partow Kebriaei
Published: 202510.1016/j.jcyt.2025.102010
Abstract
Umbilical cord blood (CB) transplantion is limited by slower engraftment and higher failure rates compared to other allografts. We hypothesized that ex vivo expansion of CB using mesenchymal progenitor cells (MPCs) and exofucosylation to enforce expr…
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