CytotherapyHumansInduced Pluripotent Stem CellsReceptorsChimeric AntigenAntigen
Chimeric synthetic T cell receptor and antigen receptor receptors enable high-sensitivity T cell receptor-negative CD8αβ-CD3-positive T-cell development from human-induced pluripotent stem cells.
Chaoqi Zhang, Michael Rassner, Yohei Kawai, Qingyi Guo, Akihiro Ishikawa, Bo Wang, Shin Kaneko
Published: 202610.1016/j.jcyt.2025.102001
Abstract
Induced pluripotent stem cell (iPSC)-derived T cells hold great promise for scalable and standardized allogeneic immunotherapies but face critical challenges in differentiation, antigen sensitivity and inaccessibility to intracellular tumor-associate…
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