Journal of controlled release : official journal of the Controlled Release Society
A new type of lipid nanoparticles with sphingomyelin-induced active lipid raft structures for improved mRNA cellular uptake.
Dandan Ling, Na Li, Xiaobin Pan, Weixiang Gao, Hao Li, Qiang Tian, Jing Li, Qin Cheng, Liang Tang, Jerry Zhang, Peng Gao, Bo Ying, Changchun Wang
Published: 202610.1016/j.jconrel.2026.114640
Abstract
Lipid nanoparticles (LNPs) are widely used as carriers for mRNA therapeutics. Although the safety of LNP has been significantly improved with evolvement of biodegradable ionizable lipids, the delivery efficiency still remains as a major challenge lim…
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