Journal of controlled release : official journal of the Controlled Release Society
Ultrafast solvent removal delivers high-loading of amorphous small-molecule drugs in polymeric microspheres with predictable in vivo performance.
Yan Lu, Linfang Liu, Xiaoyi Lv, Hongyu Ying, Jiayao Zhang, Honglin Xu, Shuai Hu, Peng Quan, Dongfei Liu
Published: 202610.1016/j.jconrel.2026.114639
Abstract
The clinical translation of long-acting injectable microspheres has been persistently hindered by manufacturing inconsistencies inherent to conventional batch processing. This variability compromises product quality and obstructs the establishment of…
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