Journal of controlled release : official journal of the Controlled Release Society
Flagella-overexpressing bacteria with inducible lysis capability delivering cGAMP intratracheally for enhanced anticancer immunotherapy.
Zhiyan Li, Yanjun Lu, Wenliang Ma, Qingwei Zeng, Hanxiao Xu, Lulu Wang, Tao Wang, Jinhui Wu
Published: 202610.1016/j.jconrel.2026.114606
Abstract
Intratracheal administration demonstrates superior therapeutic effectiveness against pulmonary diseases with reduced systemic toxicity, especially for non-small cell lung cancer (NSCLC). However, conventional intratracheally administered drugs strugg…
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