Journal of controlled release : official journal of the Controlled Release Society
Dual-targeting fluorous peptide proteolysis-targeting chimeras for cancer therapy.
Guangyu Rong, Yuhan Li, Fang Zhu, Yiteng Lu, Zhengwang Sun, Jiaxu Hong, Yiyun Cheng
Published: 202510.1016/j.jconrel.2025.114591
Abstract
Proteolysis-targeting chimeras (PROTACs) offer a powerful strategy for degrading disease-causing proteins. Simultaneous degradation of two oncogenic proteins by PROTACs can yield synergistic therapeutic effects. Here, we developed a dual-targeting fl…
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