Journal of controlled release : official journal of the Controlled Release SocietyAnimalsPancreatic NeoplasmsTumor MicroenvironmentCarcinomaPancreatic Ductal
Modulating tumor mechanics and vascular barriers to enhance chemotherapy efficacy in pancreatic tumors and melanoma.
Stella Angeli, Constantina Neophytou, Antonia Charalambous, Chrysovalantis Voutouri, Pantelia Themistokleous, Triantafyllos Stylianopoulos, Fotios Mpekris
Published: 202610.1016/j.jconrel.2025.114546
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense stroma and dysfunctional vasculature, limiting drug delivery and immune infiltration, while melanoma, though less fibrotic, remains highly metastatic and treatment-resistant. To over…
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