Journal of controlled release : official journal of the Controlled Release SocietyAnimalsTumor MicroenvironmentPancreatic NeoplasmsDoxorubicinCarcinoma
Enhancing nanomedicine efficacy in KPC pancreatic tumors through ketotifen-mediated tumor microenvironment remodeling.
Antonia Charalambous, Fotios Mpekris, Chrysovalantis Voutouri, Constantina Neophytou, José Djamus, Ajay Gupta, Alberto Gabizon, Triantafyllos Stylianopoulos
Published: 202610.1016/j.jconrel.2025.114541
Abstract
The tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC) poses major barriers to the efficacy of anticancer therapies, particularly through features such as desmoplasia, elevated stiffness, and impaired perfusion that restrict drug…
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