Journal of controlled release : official journal of the Controlled Release SocietyProdrugsDoxorubicinFatty AcidsNanoparticlesAnimals
Balancing stability and activation: A pseudoparabolic activity spectrum guides fatty acid chain length optimization in prodrug-albumin nanoparticles.
Chenxia Bai, Xiaolan Xu, Xiang Wang, Jiaming Zhang, Qing Yan, Yang Fu, Yangyang Liu, Jing Li, Lianwen Qi, Zhonggui He, Tianhong Zhang, Jin Sun, Qikun Jiang
Published: 202610.1016/j.jconrel.2025.114513
Abstract
Despite advances in prodrug-albumin nanoparticles (ANPs), critical mechanistic gaps persist-including quantitatively undefined prodrug-HSA affinity relationships, unresolved tumor-specific activation mechanisms, and suboptimal therapeutic outcomes (e…
Preview only. Read the full abstract at the source