Journal of controlled release : official journal of the Controlled Release SocietyAnimalsIntervertebral Disc DegenerationStrontiumOxidation-ReductionHomeostasis
Microenvironment-targeted strontium delivery system reshapes redox homeostasis to halt degenerative cascades in intervertebral discs.
Haozhe Cheng, Chunping A, Zixin Shu, Hongjian Zhao, Lice Wang, Chuang Huang, Wenkai Li, Xuan Fang, Hua Wu, Xing Bao, Zhong Fang
Published: 202610.1016/j.jconrel.2025.114449
Abstract
Intervertebral disc degeneration (IVDD) is mainly caused by oxidative stress, leading to cellular aging and breakdown of the extracellular matrix (ECM). Current treatments do not specifically or consistently modify the degenerative environment. To so…
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