Journal of controlled release : official journal of the Controlled Release SocietyAnimalsChitosanCancer VaccinesOvalbuminAdministration
An oral vaccine based on stable peptide-chitosan conjugate targeting DEC-205 for cancer immunotherapy.
Mengfan Wang, Xiaoyun Ye, Wanqiong Li, Danhong Chen, Xin Zhao, Peishang Shi, Xinghua Sui, Juan Liu, Feiyu Luo, Xin Yang, Xiaoshuang Niu, Youmei Xiao, Yuzhen Qian, Haoming Ning, Zhuoying He
Published: 202610.1016/j.jconrel.2025.114416
Abstract
The development of oral vaccines faces significant challenges mainly due to the harsh gastrointestinal environment and low antigen-uptake efficiency. The gut-associated lymphoid tissue (GALT), particularly Peyer's patches (PPs), contains abundant imm…
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